About Anti-Acidity Pills

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Think of acidity, and bang, a phrase most medical students are familiar with comes to mind – hurry, worry, curry. These are the three established causes of acidity. A number of other causes had been proposed throughout history, and then came the revolutionary theory that argued acidity was an infection caused by an organism called H Pylori. When the original paper was published in 1982 by Barry James Marshall, then Registrar of Medicine at the Royal Perth Hospital, and Robin Warren, a pathologist, the world laughed at the suggestion that a microorganism could survive in the acidic environment of the stomach.

Marshall insisted that he was right in spite of strong opposition he received at that point. To that effect, the adventurous Marshall drank a dish of H Pylori and developed a massive stomach inflammation, proving his point. In 2005, the pair was awarded the Nobel Prize in Physiology or Medicine. Whatever the cause of acidity, the mainstay of therapy was antacids, which every layman is known to take from time to time. At one point, every emergency in a public hospital saw one or two patients with a perforated intestine, caused due to a duodenal ulcer (upper part of the intestine).

These patients required emergency surgery before they could develop inflammation of the abdominal cavity. As young physicians we used to joke that the duodenal ulcer and appendicitis were the bread and butter of the surgeon. Then came the era of simple pop-ready antiacidity drugs. These were mostly H2 blockers like Cimetidine and Ranitidine, which blocked the secretion of acid. With the widespread use of these drugs, the stomach ulcer, which was so common, came rapidly under control and surgical instances of perforated ulcers disappeared.

By the end of the 70s, a more effective molecule to block the final step of acid secretion appeared in the market – the Proton-Pump Inhibitor (PPI). Molecules like Omeprazole and Pantaprole are effective in blocking acid secretion and a drug composed of these is now widely used. In fact, every patient admitted in an Intensive Care Unit (ICU) is administered this drug because it helps prevent stress ulcers that can form during hospitalisation. It also prevents various concomitant medication from irritating the stomach. Even today, it is rare to see an ICU patient who is not prescribed these drugs.

In August 2009 Medsafe Journalpublished a study stating that these drugs reduced the effect of a common blood thinner used in the ICU. This had the physicians concerned. Several papers suggested that some of these drugs did not affect the thinner; at the present moment there is no clear answer. The PPI is a common acidity drug sold over the counter. I have known patients advising other patients to take them because they are effective and safe.

I have seen people using it before cocktail parties and large Mughlai meals to reduce chances of acidity. Such usage may be innocuous but long-term suppression of stomach acidity has its own concern. There have been fears of stomach cancer, although not proven. One must remember the acid of the stomach has as its purpose the destruction of bacteria which may find their way to the lower intestine and cause gastroenteritis, resulting in diarrhoea. A new study by Dr Nigam Shah, assistant director of the Stanford Center for Biomedical Informatics Research, and his colleagues claims that long-term use of these drugs increases the risk of heart attack by 16 per cent. They suggest the general usage of this molecule causes more harm than good.

This study involves 2.9 million individuals and they suggest the drug interferes with the chemical (nitric oxide) in the inner lining of the heart arteries. This chemical is necessary for maintaining the heart’s health. What we did yesterday is wrong today and what we do today might be wrong tomorrow. This is evidenced in the evolution of medical theories. As of now, it is safe to say that the easy popping of so-called “can’t-do-no-harm” drugs is not as innocuous as it seems.

Source: ahmedabadmirror

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  157. Apple now has Rhapsody as an app, which is a great start, but it is currently hampered by the inability to store locally on your iPod, and has a dismal 64kbps bit rate. If this changes, then it will somewhat negate this advantage for the Zune, but the 10 songs per month will still be a big plus in Zune Pass’ favor.

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  174. Zune and iPod: Most people compare the Zune to the Touch, but after seeing how slim and surprisingly small and light it is, I consider it to be a rather unique hybrid that combines qualities of both the Touch and the Nano. It’s very colorful and lovely OLED screen is slightly smaller than the touch screen, but the player itself feels quite a bit smaller and lighter. It weighs about 2/3 as much, and is noticeably smaller in width and height, while being just a hair thicker.

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  176. Between me and my husband we’ve owned more MP3 players over the years than I can count, including Sansas, iRivers, iPods (classic & touch), the Ibiza Rhapsody, etc. But, the last few years I’ve settled down to one line of players. Why? Because I was happy to discover how well-designed and fun to use the underappreciated (and widely mocked) Zunes are.

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  187. Hands down, Apple’s app store wins by a mile. It’s a huge selection of all sorts of apps vs a rather sad selection of a handful for Zune. Microsoft has plans, especially in the realm of games, but I’m not sure I’d want to bet on the future if this aspect is important to you. The iPod is a much better choice in that case.

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  199. If you’re still on the fence: grab your favorite earphones, head down to a Best Buy and ask to plug them into a Zune then an iPod and see which one sounds better to you, and which interface makes you smile more. Then you’ll know which is right for you.

  200. The new Zune browser is surprisingly good, but not as good as the iPod’s. It works well, but isn’t as fast as Safari, and has a clunkier interface. If you occasionally plan on using the web browser that’s not an issue, but if you’re planning to browse the web alot from your PMP then the iPod’s larger screen and better browser may be important.

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  202. The Zune concentrates on being a Portable Media Player. Not a web browser. Not a game machine. Maybe in the future it’ll do even better in those areas, but for now it’s a fantastic way to organize and listen to your music and videos, and is without peer in that regard. The iPod’s strengths are its web browsing and apps. If those sound more compelling, perhaps it is your best choice.

  203. The Zune concentrates on being a Portable Media Player. Not a web browser. Not a game machine. Maybe in the future it’ll do even better in those areas, but for now it’s a fantastic way to organize and listen to your music and videos, and is without peer in that regard. The iPod’s strengths are its web browsing and apps. If those sound more compelling, perhaps it is your best choice.

  204. I’ll gear this review to 2 types of people: current Zune owners who are considering an upgrade, and people trying to decide between a Zune and an iPod. (There are other players worth considering out there, like the Sony Walkman X, but I hope this gives you enough info to make an informed decision of the Zune vs players other than the iPod line as well.)

  205. Hands down, Apple’s app store wins by a mile. It’s a huge selection of all sorts of apps vs a rather sad selection of a handful for Zune. Microsoft has plans, especially in the realm of games, but I’m not sure I’d want to bet on the future if this aspect is important to you. The iPod is a much better choice in that case.

  206. The Zune concentrates on being a Portable Media Player. Not a web browser. Not a game machine. Maybe in the future it’ll do even better in those areas, but for now it’s a fantastic way to organize and listen to your music and videos, and is without peer in that regard. The iPod’s strengths are its web browsing and apps. If those sound more compelling, perhaps it is your best choice.

  207. If you’re still on the fence: grab your favorite earphones, head down to a Best Buy and ask to plug them into a Zune then an iPod and see which one sounds better to you, and which interface makes you smile more. Then you’ll know which is right for you.

  208. This is getting a bit more subjective, but I much prefer the Zune Marketplace. The interface is colorful, has more flair, and some cool features like ‘Mixview’ that let you quickly see related albums, songs, or other users related to what you’re listening to. Clicking on one of those will center on that item, and another set of “neighbors” will come into view, allowing you to navigate around exploring by similar artists, songs, or users. Speaking of users, the Zune “Social” is also great fun, letting you find others with shared tastes and becoming friends with them. You then can listen to a playlist created based on an amalgamation of what all your friends are listening to, which is also enjoyable. Those concerned with privacy will be relieved to know you can prevent the public from seeing your personal listening habits if you so choose.

  209. If you’re still on the fence: grab your favorite earphones, head down to a Best Buy and ask to plug them into a Zune then an iPod and see which one sounds better to you, and which interface makes you smile more. Then you’ll know which is right for you.

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  211. The Zune concentrates on being a Portable Media Player. Not a web browser. Not a game machine. Maybe in the future it’ll do even better in those areas, but for now it’s a fantastic way to organize and listen to your music and videos, and is without peer in that regard. The iPod’s strengths are its web browsing and apps. If those sound more compelling, perhaps it is your best choice.

  212. The Zune concentrates on being a Portable Media Player. Not a web browser. Not a game machine. Maybe in the future it’ll do even better in those areas, but for now it’s a fantastic way to organize and listen to your music and videos, and is without peer in that regard. The iPod’s strengths are its web browsing and apps. If those sound more compelling, perhaps it is your best choice.

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  214. Hands down, Apple’s app store wins by a mile. It’s a huge selection of all sorts of apps vs a rather sad selection of a handful for Zune. Microsoft has plans, especially in the realm of games, but I’m not sure I’d want to bet on the future if this aspect is important to you. The iPod is a much better choice in that case.

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  261. The new Zune browser is surprisingly good, but not as good as the iPod’s. It works well, but isn’t as fast as Safari, and has a clunkier interface. If you occasionally plan on using the web browser that’s not an issue, but if you’re planning to browse the web alot from your PMP then the iPod’s larger screen and better browser may be important.

  262. Hands down, Apple’s app store wins by a mile. It’s a huge selection of all sorts of apps vs a rather sad selection of a handful for Zune. Microsoft has plans, especially in the realm of games, but I’m not sure I’d want to bet on the future if this aspect is important to you. The iPod is a much better choice in that case.

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  265. The Zune concentrates on being a Portable Media Player. Not a web browser. Not a game machine. Maybe in the future it’ll do even better in those areas, but for now it’s a fantastic way to organize and listen to your music and videos, and is without peer in that regard. The iPod’s strengths are its web browsing and apps. If those sound more compelling, perhaps it is your best choice.

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  267. If you’re still on the fence: grab your favorite earphones, head down to a Best Buy and ask to plug them into a Zune then an iPod and see which one sounds better to you, and which interface makes you smile more. Then you’ll know which is right for you.

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  273. Sorry for the huge review, but I’m really loving the new Zune, and hope this, as well as the excellent reviews some other people have written, will help you decide if it’s the right choice for you.

  274. The new Zune browser is surprisingly good, but not as good as the iPod’s. It works well, but isn’t as fast as Safari, and has a clunkier interface. If you occasionally plan on using the web browser that’s not an issue, but if you’re planning to browse the web alot from your PMP then the iPod’s larger screen and better browser may be important.

  275. Zune and iPod: Most people compare the Zune to the Touch, but after seeing how slim and surprisingly small and light it is, I consider it to be a rather unique hybrid that combines qualities of both the Touch and the Nano. It’s very colorful and lovely OLED screen is slightly smaller than the touch screen, but the player itself feels quite a bit smaller and lighter. It weighs about 2/3 as much, and is noticeably smaller in width and height, while being just a hair thicker.

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