Calcium and Vitamin D Supplements

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Calcium and vitamin D supplementation may cause hypercalciuria and hypercalcemia in some postmenopausal women, according to a randomized, double-blind, placebo-controlled study. Clinicians should measure blood and urine calcium levels at baseline and every 3 months in women who take the supplements, the researchers say.

John Christopher Gallagher, MD, from the Bone Metabolism Unit, Creighton University, Omaha, Nebraska, and colleagues present the results of their prospective study in an article published online June 16 in Menopause.

After women turn 40 years old, they lose 0.5% to 1% of bone per year, according to the National Institutes of Health. Calcium and vitamin D supplements are given to many postmenopausal women for the prevention of osteoporosis, the authors write. The recommended dietary allowance for vitamin D3 is 600 to 800 IU/day, and the recommended dietary allowance for calcium is 1200 mg/day.

Previous research has reported an increased risk for nephrolithiasis in women who take calcium and vitamin D supplements compared with placebo.

The researchers included 163 white women aged 57 to 90 years in the study. All women were deficient in vitamin D at baseline, with serum 25-hydroxy vitamin D levels lower than 20 ng/mL (50 nmol/L).

The researchers randomly assigned women to receive vitamin D3400, 800, 1600, 2400, 3200, 4000, or 4800 IU/day or placebo. They analyzed the women’s dietary calcium levels from 7-day food diaries and gave them daily calcium citrate supplements to maintain total calcium intake between 1200 and 1400 mg/day.

The researchers collected serum and 24-hour urine calcium every 3 months during supplementation, and they considered any test result above the upper reference range to be an episode of hypercalcemia or hypercalciuria.

A total of 147 women completed the 1-year study protocol. Of those participants, 8.8% experienced hypercalcemia (910.2 mg/dL [2.55 mmol/L]) and 30.6% experienced hypercalciuria (9300 mg/d [7.5 mmol]). Hypercalciuria episodes were transient in half the group and recurred in the other half. The researchers found no relationship between hypercalcemia or hypercalciuria and vitamin D dose, and hypercalciuria was equally frequent in the placebo group.

“No relationship was found between episodes of hypercalcemia or hypercalciuria and vitamin D3 dose or serum 25(OH)D level, but 24-hour urine calcium was weakly related to the 12-month serum 25(OH)D level,” the authors write.

For women whose baseline 24-hour urine calcium level was above 132 mg, their risk of developing hypercalciuria was 15 times higher than that of women with lower levels. That risk was 20 times higher for women whose baseline levels were above 180 mg. Their risk reduced by 10% with every 1-year increase in age.

Source: medscape

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  123. Apple now has Rhapsody as an app, which is a great start, but it is currently hampered by the inability to store locally on your iPod, and has a dismal 64kbps bit rate. If this changes, then it will somewhat negate this advantage for the Zune, but the 10 songs per month will still be a big plus in Zune Pass’ favor.

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  134. Zune and iPod: Most people compare the Zune to the Touch, but after seeing how slim and surprisingly small and light it is, I consider it to be a rather unique hybrid that combines qualities of both the Touch and the Nano. It’s very colorful and lovely OLED screen is slightly smaller than the touch screen, but the player itself feels quite a bit smaller and lighter. It weighs about 2/3 as much, and is noticeably smaller in width and height, while being just a hair thicker.

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  136. The Zune concentrates on being a Portable Media Player. Not a web browser. Not a game machine. Maybe in the future it’ll do even better in those areas, but for now it’s a fantastic way to organize and listen to your music and videos, and is without peer in that regard. The iPod’s strengths are its web browsing and apps. If those sound more compelling, perhaps it is your best choice.

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  140. I’ll gear this review to 2 types of people: current Zune owners who are considering an upgrade, and people trying to decide between a Zune and an iPod. (There are other players worth considering out there, like the Sony Walkman X, but I hope this gives you enough info to make an informed decision of the Zune vs players other than the iPod line as well.)

  141. I’ll gear this review to 2 types of people: current Zune owners who are considering an upgrade, and people trying to decide between a Zune and an iPod. (There are other players worth considering out there, like the Sony Walkman X, but I hope this gives you enough info to make an informed decision of the Zune vs players other than the iPod line as well.)

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  145. Hands down, Apple’s app store wins by a mile. It’s a huge selection of all sorts of apps vs a rather sad selection of a handful for Zune. Microsoft has plans, especially in the realm of games, but I’m not sure I’d want to bet on the future if this aspect is important to you. The iPod is a much better choice in that case.

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  156. Zune and iPod: Most people compare the Zune to the Touch, but after seeing how slim and surprisingly small and light it is, I consider it to be a rather unique hybrid that combines qualities of both the Touch and the Nano. It’s very colorful and lovely OLED screen is slightly smaller than the touch screen, but the player itself feels quite a bit smaller and lighter. It weighs about 2/3 as much, and is noticeably smaller in width and height, while being just a hair thicker.

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  160. The Zune concentrates on being a Portable Media Player. Not a web browser. Not a game machine. Maybe in the future it’ll do even better in those areas, but for now it’s a fantastic way to organize and listen to your music and videos, and is without peer in that regard. The iPod’s strengths are its web browsing and apps. If those sound more compelling, perhaps it is your best choice.

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  163. Zune and iPod: Most people compare the Zune to the Touch, but after seeing how slim and surprisingly small and light it is, I consider it to be a rather unique hybrid that combines qualities of both the Touch and the Nano. It’s very colorful and lovely OLED screen is slightly smaller than the touch screen, but the player itself feels quite a bit smaller and lighter. It weighs about 2/3 as much, and is noticeably smaller in width and height, while being just a hair thicker.

  164. Hands down, Apple’s app store wins by a mile. It’s a huge selection of all sorts of apps vs a rather sad selection of a handful for Zune. Microsoft has plans, especially in the realm of games, but I’m not sure I’d want to bet on the future if this aspect is important to you. The iPod is a much better choice in that case.

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  167. The new Zune browser is surprisingly good, but not as good as the iPod’s. It works well, but isn’t as fast as Safari, and has a clunkier interface. If you occasionally plan on using the web browser that’s not an issue, but if you’re planning to browse the web alot from your PMP then the iPod’s larger screen and better browser may be important.

  168. Between me and my husband we’ve owned more MP3 players over the years than I can count, including Sansas, iRivers, iPods (classic & touch), the Ibiza Rhapsody, etc. But, the last few years I’ve settled down to one line of players. Why? Because I was happy to discover how well-designed and fun to use the underappreciated (and widely mocked) Zunes are.

  169. The Zune concentrates on being a Portable Media Player. Not a web browser. Not a game machine. Maybe in the future it’ll do even better in those areas, but for now it’s a fantastic way to organize and listen to your music and videos, and is without peer in that regard. The iPod’s strengths are its web browsing and apps. If those sound more compelling, perhaps it is your best choice.

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  173. Apple now has Rhapsody as an app, which is a great start, but it is currently hampered by the inability to store locally on your iPod, and has a dismal 64kbps bit rate. If this changes, then it will somewhat negate this advantage for the Zune, but the 10 songs per month will still be a big plus in Zune Pass’ favor.

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  182. The new Zune browser is surprisingly good, but not as good as the iPod’s. It works well, but isn’t as fast as Safari, and has a clunkier interface. If you occasionally plan on using the web browser that’s not an issue, but if you’re planning to browse the web alot from your PMP then the iPod’s larger screen and better browser may be important.

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