Experts discover new enzyme, link to iron in vitamin A synthesis

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A research team’s discovery of new information about how plants synthesize carotenoids, precursors for vitamin A that are essential for plant development and survival, and human health, could help scientists increase the levels of provitamin A in food crops and reduce global vitamin A deficiency.

The World Health Organization estimates 250 million children suffer from vitamin A deficiency. Vitamin A deficiency is the leading cause of preventable blindness and increases the risk of disease and death from severe infections. It is a public health problem in more than half of all countries, especially in Africa and Southeast Asia, having a significant impact on young children and pregnant women in low-income countries, according to the World Health Organization.

This global problem has sparked worldwide efforts to increase the levels of provitamin A carotenoids in food crops. To achieve this, scientists must gain further knowledge of how plants control and biosynthesize carotenoids that can be converted to vitamin A in humans.

The findings, published June 15 in Nature Chemical Biology, highlight the team’s discovery of a new enzyme that is critical for the biosynthesis of vitamin A in plants and its unexpected dependence on heme iron. This heme iron allows the enzyme to make the necessary structural changes to complete the chemical mechanism for making vitamin A.

Scientists from Georgia State University, City University of New York, New York Structural Biology Center, University of Mississippi Medical Center, University of South Carolina, Georgia Institute of Technology, New Zealand Institute for Plant and Food Research Limited and Albert Einstein College of Medicine collaborated to find out how vitamin A is synthesized in plants.

This study confirmed that 15-cis-ζ-carotene isomerase (Z-ISO) is an enzyme and integral membrane protein. It also found that Z-ISO independently catalyzes the cis-trans isomerization, or chemical reaction that changes the structural conformation of a compound, of the central carbon double bond to produce the required molecule upon which the enzyme acts for the pathway.

“We identified this enzyme plays a significant role in synthesizing vitamin A. This is one critical step to get vitamin A compounds,” said Dr. Aimin Liu, Distinguished University Professor of chemistry and biochemistry at Georgia State. “It is really unique in the biosynthetic pathway because it’s a relatively large-sized organic molecule. Until recently, it wasn’t known which gene product is responsible for these reactions.”

Liu and his group used electron paramagnetic resonance (EPR) spectroscopy, which is extremely sensitive to electronic structures, and concluded that Z-ISO is a heme-based protein. Heme is a large, organic system with a metal iron in the center. It is well known because of its red color and presence in red blood cells.

“It’s quite surprising to us for a chemical reaction to use heme,” Liu said. “It’s really new for the chemical field. It’s a really large molecule, a very long chain with many double and single bonds. It does not typically allow large molecules to come in. There’s not much room to play. We discovered surprisingly that it’s an isomerase reaction catalyzed by a heme protein.”

EPR spectroscopy revealed the heme center starts as Fe(III) and is reduced to Fe(II), creating room for structural change and a pocket for the Z-ISO enzyme. The heme center rotates the Z-ISO enzyme 180 degrees from the cis orientation, with two groups on the same side, into the thermodynamically favorable trans orientation, which has two groups on opposite sides. The reduction from Fe(III) to Fe(II) is necessary for enzyme activity, Liu said.

“After that, the product can become vitamin A. You still need one to two steps to complete synthesis of vitamin A, but this is the most intriguing step chemically,” Liu said.

The findings are significant for those interested in vitamin synthesis, plant biology, plant biochemistry, enzymology and heme proteins, he said.

“It’s important to understand this molecular mechanism so in the future we could generate synthetic compounds or modify the forms for different medical purposes,” Liu said.

 Source : Science Daily

 

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  177. If you’re still on the fence: grab your favorite earphones, head down to a Best Buy and ask to plug them into a Zune then an iPod and see which one sounds better to you, and which interface makes you smile more. Then you’ll know which is right for you.

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  182. Apple now has Rhapsody as an app, which is a great start, but it is currently hampered by the inability to store locally on your iPod, and has a dismal 64kbps bit rate. If this changes, then it will somewhat negate this advantage for the Zune, but the 10 songs per month will still be a big plus in Zune Pass’ favor.

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  190. The Zune concentrates on being a Portable Media Player. Not a web browser. Not a game machine. Maybe in the future it’ll do even better in those areas, but for now it’s a fantastic way to organize and listen to your music and videos, and is without peer in that regard. The iPod’s strengths are its web browsing and apps. If those sound more compelling, perhaps it is your best choice.

  191. Very nice post and straight to the point. I am not sure if this is in fact the best place to ask but do you guys have any ideea where to get some professional writers? Thank you :)

  192. This is getting a bit more subjective, but I much prefer the Zune Marketplace. The interface is colorful, has more flair, and some cool features like ‘Mixview’ that let you quickly see related albums, songs, or other users related to what you’re listening to. Clicking on one of those will center on that item, and another set of “neighbors” will come into view, allowing you to navigate around exploring by similar artists, songs, or users. Speaking of users, the Zune “Social” is also great fun, letting you find others with shared tastes and becoming friends with them. You then can listen to a playlist created based on an amalgamation of what all your friends are listening to, which is also enjoyable. Those concerned with privacy will be relieved to know you can prevent the public from seeing your personal listening habits if you so choose.

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  194. This is getting a bit more subjective, but I much prefer the Zune Marketplace. The interface is colorful, has more flair, and some cool features like ‘Mixview’ that let you quickly see related albums, songs, or other users related to what you’re listening to. Clicking on one of those will center on that item, and another set of “neighbors” will come into view, allowing you to navigate around exploring by similar artists, songs, or users. Speaking of users, the Zune “Social” is also great fun, letting you find others with shared tastes and becoming friends with them. You then can listen to a playlist created based on an amalgamation of what all your friends are listening to, which is also enjoyable. Those concerned with privacy will be relieved to know you can prevent the public from seeing your personal listening habits if you so choose.

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  206. The Zune concentrates on being a Portable Media Player. Not a web browser. Not a game machine. Maybe in the future it’ll do even better in those areas, but for now it’s a fantastic way to organize and listen to your music and videos, and is without peer in that regard. The iPod’s strengths are its web browsing and apps. If those sound more compelling, perhaps it is your best choice.

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  208. The Zune concentrates on being a Portable Media Player. Not a web browser. Not a game machine. Maybe in the future it’ll do even better in those areas, but for now it’s a fantastic way to organize and listen to your music and videos, and is without peer in that regard. The iPod’s strengths are its web browsing and apps. If those sound more compelling, perhaps it is your best choice.

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  213. The new Zune browser is surprisingly good, but not as good as the iPod’s. It works well, but isn’t as fast as Safari, and has a clunkier interface. If you occasionally plan on using the web browser that’s not an issue, but if you’re planning to browse the web alot from your PMP then the iPod’s larger screen and better browser may be important.

  214. Apple now has Rhapsody as an app, which is a great start, but it is currently hampered by the inability to store locally on your iPod, and has a dismal 64kbps bit rate. If this changes, then it will somewhat negate this advantage for the Zune, but the 10 songs per month will still be a big plus in Zune Pass’ favor.

  215. Between me and my husband we’ve owned more MP3 players over the years than I can count, including Sansas, iRivers, iPods (classic & touch), the Ibiza Rhapsody, etc. But, the last few years I’ve settled down to one line of players. Why? Because I was happy to discover how well-designed and fun to use the underappreciated (and widely mocked) Zunes are.

  216. This is getting a bit more subjective, but I much prefer the Zune Marketplace. The interface is colorful, has more flair, and some cool features like ‘Mixview’ that let you quickly see related albums, songs, or other users related to what you’re listening to. Clicking on one of those will center on that item, and another set of “neighbors” will come into view, allowing you to navigate around exploring by similar artists, songs, or users. Speaking of users, the Zune “Social” is also great fun, letting you find others with shared tastes and becoming friends with them. You then can listen to a playlist created based on an amalgamation of what all your friends are listening to, which is also enjoyable. Those concerned with privacy will be relieved to know you can prevent the public from seeing your personal listening habits if you so choose.

  217. I’ll gear this review to 2 types of people: current Zune owners who are considering an upgrade, and people trying to decide between a Zune and an iPod. (There are other players worth considering out there, like the Sony Walkman X, but I hope this gives you enough info to make an informed decision of the Zune vs players other than the iPod line as well.)

  218. If you’re still on the fence: grab your favorite earphones, head down to a Best Buy and ask to plug them into a Zune then an iPod and see which one sounds better to you, and which interface makes you smile more. Then you’ll know which is right for you.

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  221. If you’re still on the fence: grab your favorite earphones, head down to a Best Buy and ask to plug them into a Zune then an iPod and see which one sounds better to you, and which interface makes you smile more. Then you’ll know which is right for you.

  222. This is getting a bit more subjective, but I much prefer the Zune Marketplace. The interface is colorful, has more flair, and some cool features like ‘Mixview’ that let you quickly see related albums, songs, or other users related to what you’re listening to. Clicking on one of those will center on that item, and another set of “neighbors” will come into view, allowing you to navigate around exploring by similar artists, songs, or users. Speaking of users, the Zune “Social” is also great fun, letting you find others with shared tastes and becoming friends with them. You then can listen to a playlist created based on an amalgamation of what all your friends are listening to, which is also enjoyable. Those concerned with privacy will be relieved to know you can prevent the public from seeing your personal listening habits if you so choose.

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  225. Hands down, Apple’s app store wins by a mile. It’s a huge selection of all sorts of apps vs a rather sad selection of a handful for Zune. Microsoft has plans, especially in the realm of games, but I’m not sure I’d want to bet on the future if this aspect is important to you. The iPod is a much better choice in that case.

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  228. If you’re still on the fence: grab your favorite earphones, head down to a Best Buy and ask to plug them into a Zune then an iPod and see which one sounds better to you, and which interface makes you smile more. Then you’ll know which is right for you.

  229. The Zune concentrates on being a Portable Media Player. Not a web browser. Not a game machine. Maybe in the future it’ll do even better in those areas, but for now it’s a fantastic way to organize and listen to your music and videos, and is without peer in that regard. The iPod’s strengths are its web browsing and apps. If those sound more compelling, perhaps it is your best choice.

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  232. This is getting a bit more subjective, but I much prefer the Zune Marketplace. The interface is colorful, has more flair, and some cool features like ‘Mixview’ that let you quickly see related albums, songs, or other users related to what you’re listening to. Clicking on one of those will center on that item, and another set of “neighbors” will come into view, allowing you to navigate around exploring by similar artists, songs, or users. Speaking of users, the Zune “Social” is also great fun, letting you find others with shared tastes and becoming friends with them. You then can listen to a playlist created based on an amalgamation of what all your friends are listening to, which is also enjoyable. Those concerned with privacy will be relieved to know you can prevent the public from seeing your personal listening habits if you so choose.

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  262. Zune and iPod: Most people compare the Zune to the Touch, but after seeing how slim and surprisingly small and light it is, I consider it to be a rather unique hybrid that combines qualities of both the Touch and the Nano. It’s very colorful and lovely OLED screen is slightly smaller than the touch screen, but the player itself feels quite a bit smaller and lighter. It weighs about 2/3 as much, and is noticeably smaller in width and height, while being just a hair thicker.

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