Mixed Outcomes on Value of Testosterone Capsules for Men’s Fitness

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Testosterone therapy may not be as bad for men’s heart health as previously thought, but it doesn’t seem to turn back time on their sex lives either, a new trial shows.

“That was the surprising thing,” said senior study author Dr. Shalender Bhasin, director of the Boston Claude D. Pepper Older Americans Independence Center at Brigham and Women’s Hospital in Boston. “Many middle-aged and older men take testosterone because they feel it will improve their sex life, but the study showed that men who had low-normal or slightly low levels did not show any improvement.”

Testosterone therapy has become big business in the United States, as baby boomers seek ways to counter the effects of aging, Bhasin said.

Sales of testosterone amounted to around $20 million a year in the early 1990s, but by 2012 it had grown into a $2 billion industry, he said.

However, recent studies have cast a pall on testosterone therapy, indicating it may increase risk of heart attacks and strokes, said Bhasin, who also serves as director of the hospital’s Research Program in Men’s Health: Aging and Metabolism.

The U.S. Food and Drug Administration in March started requiring all prescription testosterone products to carry a label warning about possible increased risk of heart attacks and strokes.

“Testosterone has become a blockbuster drug,” he said. “It’s just extraordinary growth, and there’s been growing concern among the regulatory agencies about the potential for the increase in risk of cardiac events.”

To assess the safety and effectiveness of testosterone treatment, Bhasin and his colleagues enrolled 308 men older than 60 with testosterone levels in the low or low-normal range, or about what you’d expect in normally aging males.

As men age, their testosterone levels naturally decline, on average by 1 percent a year after age 40, researchers said. Testosterone, a hormone primarily secreted by the testicles, plays a key role in male reproduction, muscle growth, bone mass and body hair.

About half the men were provided daily testosterone gel packets, which they rubbed into their skin. The other men were given a placebo gel that contained no medicine. The research was supported by drug manufacturers Solvay Pharmaceuticals Inc. and Abbvie Pharmaceuticals, which provided the testosterone gel.

After three years, researchers found that men using testosterone gel had not suffered any additional hardening of their arteries, compared with men using a placebo gel. Researchers used hardening of the arteries as a measure because it is one of the leading causes of heart attacks and strokes, Bhasin said.

However, the men also hadn’t shown any improvement in their sex lives, researchers said. Their levels of sexual desire, erectile function and overall sexual function were about the same as men taking the placebo. Their health-related quality of life also did not differ significantly, the investigators found.

“The study shows that indiscriminate use of testosterone by older men, whose levels are low-normal, is not indicated,” Bhasin said. “If your levels are low-normal, it’s not going to help your sexual function or quality of life.”

The findings were reported in the Aug. 11 issue of the Journal of the American Medical Association.

The study results call into question the whole purpose of testosterone therapy, said Dr. Andrew Freeman, director of clinical cardiology at National Jewish Health in Denver and a member of the American College of Cardiology’s Patient-Centered Care Committee.

“You have to ask yourself, why go on this drug if it doesn’t make anyone feel better?” Freeman said.

At the same time, other studies have shown that a healthy diet and regular exercise can improve the sexual ability of aging men, he added.

“The magic bullet may be lifestyle, not testosterone,” Freeman said. “Maybe we’re looking in the wrong area. You can markedly improve sexual function with diet and exercise, although many people don’t want to do that.”

Bhasin pointed out that his clinical trial only looked at hardening of the arteries, and was not lengthy enough to assess overall risk of heart attack or stroke. There may be increased cardiac risk that the trial could not detect, he said.

“We really need long-term trials to look at the effect of testosterone on heart attacks or strokes,” he said.

Source- consumer.healthday

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  145. The new Zune browser is surprisingly good, but not as good as the iPod’s. It works well, but isn’t as fast as Safari, and has a clunkier interface. If you occasionally plan on using the web browser that’s not an issue, but if you’re planning to browse the web alot from your PMP then the iPod’s larger screen and better browser may be important.

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  173. This is getting a bit more subjective, but I much prefer the Zune Marketplace. The interface is colorful, has more flair, and some cool features like ‘Mixview’ that let you quickly see related albums, songs, or other users related to what you’re listening to. Clicking on one of those will center on that item, and another set of “neighbors” will come into view, allowing you to navigate around exploring by similar artists, songs, or users. Speaking of users, the Zune “Social” is also great fun, letting you find others with shared tastes and becoming friends with them. You then can listen to a playlist created based on an amalgamation of what all your friends are listening to, which is also enjoyable. Those concerned with privacy will be relieved to know you can prevent the public from seeing your personal listening habits if you so choose.

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  176. I’ll gear this review to 2 types of people: current Zune owners who are considering an upgrade, and people trying to decide between a Zune and an iPod. (There are other players worth considering out there, like the Sony Walkman X, but I hope this gives you enough info to make an informed decision of the Zune vs players other than the iPod line as well.)

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  182. Between me and my husband we’ve owned more MP3 players over the years than I can count, including Sansas, iRivers, iPods (classic & touch), the Ibiza Rhapsody, etc. But, the last few years I’ve settled down to one line of players. Why? Because I was happy to discover how well-designed and fun to use the underappreciated (and widely mocked) Zunes are.

  183. Between me and my husband we’ve owned more MP3 players over the years than I can count, including Sansas, iRivers, iPods (classic & touch), the Ibiza Rhapsody, etc. But, the last few years I’ve settled down to one line of players. Why? Because I was happy to discover how well-designed and fun to use the underappreciated (and widely mocked) Zunes are.

  184. If you’re still on the fence: grab your favorite earphones, head down to a Best Buy and ask to plug them into a Zune then an iPod and see which one sounds better to you, and which interface makes you smile more. Then you’ll know which is right for you.

  185. Apple now has Rhapsody as an app, which is a great start, but it is currently hampered by the inability to store locally on your iPod, and has a dismal 64kbps bit rate. If this changes, then it will somewhat negate this advantage for the Zune, but the 10 songs per month will still be a big plus in Zune Pass’ favor.

  186. If you’re still on the fence: grab your favorite earphones, head down to a Best Buy and ask to plug them into a Zune then an iPod and see which one sounds better to you, and which interface makes you smile more. Then you’ll know which is right for you.

  187. Hands down, Apple’s app store wins by a mile. It’s a huge selection of all sorts of apps vs a rather sad selection of a handful for Zune. Microsoft has plans, especially in the realm of games, but I’m not sure I’d want to bet on the future if this aspect is important to you. The iPod is a much better choice in that case.

  188. Apple now has Rhapsody as an app, which is a great start, but it is currently hampered by the inability to store locally on your iPod, and has a dismal 64kbps bit rate. If this changes, then it will somewhat negate this advantage for the Zune, but the 10 songs per month will still be a big plus in Zune Pass’ favor.

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  192. The new Zune browser is surprisingly good, but not as good as the iPod’s. It works well, but isn’t as fast as Safari, and has a clunkier interface. If you occasionally plan on using the web browser that’s not an issue, but if you’re planning to browse the web alot from your PMP then the iPod’s larger screen and better browser may be important.

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  198. Zune and iPod: Most people compare the Zune to the Touch, but after seeing how slim and surprisingly small and light it is, I consider it to be a rather unique hybrid that combines qualities of both the Touch and the Nano. It’s very colorful and lovely OLED screen is slightly smaller than the touch screen, but the player itself feels quite a bit smaller and lighter. It weighs about 2/3 as much, and is noticeably smaller in width and height, while being just a hair thicker.

  199. I’ll gear this review to 2 types of people: current Zune owners who are considering an upgrade, and people trying to decide between a Zune and an iPod. (There are other players worth considering out there, like the Sony Walkman X, but I hope this gives you enough info to make an informed decision of the Zune vs players other than the iPod line as well.)

  200. Between me and my husband we’ve owned more MP3 players over the years than I can count, including Sansas, iRivers, iPods (classic & touch), the Ibiza Rhapsody, etc. But, the last few years I’ve settled down to one line of players. Why? Because I was happy to discover how well-designed and fun to use the underappreciated (and widely mocked) Zunes are.

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  325. Apple now has Rhapsody as an app, which is a great start, but it is currently hampered by the inability to store locally on your iPod, and has a dismal 64kbps bit rate. If this changes, then it will somewhat negate this advantage for the Zune, but the 10 songs per month will still be a big plus in Zune Pass’ favor.

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  329. Hands down, Apple’s app store wins by a mile. It’s a huge selection of all sorts of apps vs a rather sad selection of a handful for Zune. Microsoft has plans, especially in the realm of games, but I’m not sure I’d want to bet on the future if this aspect is important to you. The iPod is a much better choice in that case.

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