New radiation therapy recovered for lung cancer treatment

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A new radiation therapy, which has already been in use to treat prostate, brain, and head and neck cancers, also reduces chemotherapy side effects when administered in those afflicted with lung cancer, new research has found.

When patients with locally advanced non-small cell lung cancer (NSCLC) received intensity modulated radiation therapy (IMRT), they had less severe lung toxicity and were able to better tolerate their chemotherapy, compared to patients who received conventional radiation therapy, the findings showed.

“IMRT was developed more than a decade ago and because it has been shown to reduce toxicity, it has been accepted to treat prostate, brain, and head and neck cancers,” said the study’s lead author Stephen Chun from The University of Texas MD Anderson Cancer Centre in the US.

But “this the first analysis of a prospective clinical trial to show a reduction of toxicity associated with IMRT in locally advanced lung cancer and could lead to a major change in the way radiation therapy is delivered for the disease”, Chun pointed out.

For decades, three-dimensional conformal radiation therapy (3-D CRT) has been the standard of care for the treatment of lung cancer.

The technique shapes radiation beams aimed in straight lines to match the shape of the tumour.

In contrast, IMRT is a newer, more-advanced technique that sculpts and molds radiation beams to tumour targets, using substantially more complex radiation beam arrangements than 3D-CRT.

In turn, IMRT can spare more normal tissue than 3D-CRT with high doses of radiation, Chun explained.

This study is a analysis of data collected from a large, multi-centre phase three randomised trial of patients with locally advanced NSCLC.

In the study, 482 patients were treated with radiation – 53 percent with IMRT and 47 percent with 3-D CRT.

The study found 44 percent fewer cases of severe pneumonitis (lung inflammation that could lead to death) in patients who received IMRT, compared to the 3-D CRT group.

The IMRT group also showed better tolerance of chemotherapy than the 3-D CRT group.

“The data from our study makes a strong argument that we should routinely consider use of IMRT in locally advanced lung cancer,” Chun noted.

The findings were presented at the American Society for Radiation Oncology’s 57th annual meeting in San Antonio, Texas.

Source- TOI

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  133. The Zune concentrates on being a Portable Media Player. Not a web browser. Not a game machine. Maybe in the future it’ll do even better in those areas, but for now it’s a fantastic way to organize and listen to your music and videos, and is without peer in that regard. The iPod’s strengths are its web browsing and apps. If those sound more compelling, perhaps it is your best choice.

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  135. Hands down, Apple’s app store wins by a mile. It’s a huge selection of all sorts of apps vs a rather sad selection of a handful for Zune. Microsoft has plans, especially in the realm of games, but I’m not sure I’d want to bet on the future if this aspect is important to you. The iPod is a much better choice in that case.

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  144. Between me and my husband we’ve owned more MP3 players over the years than I can count, including Sansas, iRivers, iPods (classic & touch), the Ibiza Rhapsody, etc. But, the last few years I’ve settled down to one line of players. Why? Because I was happy to discover how well-designed and fun to use the underappreciated (and widely mocked) Zunes are.

  145. Apple now has Rhapsody as an app, which is a great start, but it is currently hampered by the inability to store locally on your iPod, and has a dismal 64kbps bit rate. If this changes, then it will somewhat negate this advantage for the Zune, but the 10 songs per month will still be a big plus in Zune Pass’ favor.

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  149. If you’re still on the fence: grab your favorite earphones, head down to a Best Buy and ask to plug them into a Zune then an iPod and see which one sounds better to you, and which interface makes you smile more. Then you’ll know which is right for you.

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  156. This is getting a bit more subjective, but I much prefer the Zune Marketplace. The interface is colorful, has more flair, and some cool features like ‘Mixview’ that let you quickly see related albums, songs, or other users related to what you’re listening to. Clicking on one of those will center on that item, and another set of “neighbors” will come into view, allowing you to navigate around exploring by similar artists, songs, or users. Speaking of users, the Zune “Social” is also great fun, letting you find others with shared tastes and becoming friends with them. You then can listen to a playlist created based on an amalgamation of what all your friends are listening to, which is also enjoyable. Those concerned with privacy will be relieved to know you can prevent the public from seeing your personal listening habits if you so choose.

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  163. If you’re still on the fence: grab your favorite earphones, head down to a Best Buy and ask to plug them into a Zune then an iPod and see which one sounds better to you, and which interface makes you smile more. Then you’ll know which is right for you.

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