Pyroluria is a unique metabolic condition that is very rarely recognized in both the medical and natural health world. Some researchers in the orthomolecular medicine and orthomolecular psychiatry believe that up to 10 percent of the population has this metabolic condition. It is considered by many in the functional medicine world the most common unknown disorder. Pyrolurics need a specific diet, lifestyle and supplementation program to get well.
Pyroluria is a genetic condition that is typically related to familial alcoholism and/or environmental toxicity. If an individual has a family history of alcoholism they may very well have this genetic mutation. It can be induced with childhood trauma or a chronic infection early in life. The onset usually begins in the late teens and is often triggered by a traumatic life event.
The symptoms associated with pyroluria
It is estimated that as many as 50 percent of those with autism, 40 percent of alcoholics, 70 percent of schizophrenics, 70 percent of depressed individuals and 30 percent of people with ADHD have pyroluria. The symptoms of pyroluria include chronic anxiety, poor stress tolerance, digestive issues, poor immunity, joint pain, acne or eczema, mood swings and poor short term memory. These individuals often have difficulty digesting and absorbing protein and they are easily wrecked by increasing stress.
Pyroluria can be diagnosed through a specific Kryptopyrroles urine test. Normal amounts of kryptophyrroles in the urine should be less than 20 ug/dl. Numbers greater than 20 ug/dl would be a positive test for the diagnosis of pyroluria. Other warning signs you may have this disorder include an inability to remember dreams, hair loss, light, thin pale skin that is prone to stretch marks, white spots on the fingernails and poor tooth enamel.
What is pyroluria
There are several waste products that are produced when the body makes hemoglobin for the red blood cells. These waste products are called kryptopyrroles which are technically called hydroxyhemoppyrrolin-2-one (HPL) which are typically excreted by our body. Individuals with pyroluria are unable to clear the HPL effectively and they build up in the system.
The HPL binds strongly to zinc, biotin and vitamin B6 which are critical nutrients for cellular metabolism. Over a period of time, the body becomes very deficient in these critical nutrients and symptoms arise. These people will often go years suffering the effects of this disorder despite a clean diet, supplementation and holistic therapies.
Nutrition and supplementation for pyrolurics
Pyrolurics have a greater need for omega-6 fatty acids than most in our society. They need both arachidonic acid (AA) and Gamma linolenic acid (GLA). A diet rich in pastured eggs, pasture-fed butter, grass-fed beef and wild game and organ meats supplies the body with significant amounts of essential fats. GLA is found in evening primrose oil, black current seed oil and hemp oil. This is typically supplemented.
These individuals need to supplement with zinc and co-enzymated form of vitamin B6 called P-5-P. A general methyl donating supplement with P-5-P and other methyl donors such as trimethylglycine, folate, B12, choline and betaine HCL is quite effect with this process. The betaine HCL also helps with stomach acid production which is low in pyrolurics. Probiotics and fermented foods are also necessary for these individuals to reduce inflammatory gut related stress and heal appropriately.
Results with proper lifestyle and supplementation
With the right diet, supplementation and stress reduction most pyrolurics see results very quickly. More severe cases usually experience slow progressive results. Very stubborn cases are typically having issues with heavy metals or mold toxins.
They will need to remain on this lifestyle with moderate supplementation for the rest of their life or risk symptoms coming back. Typically, large doses of supplementation is used in the beginning and the individual tapers down to smaller doses as they feel better and have a return to nutrient sufficient status.
Source : Natural News