Reduced serum vitamin D levels associated with increased risk of nonalcoholic fatty liver disease

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Findings from Shanghai Jiao-Tong University Yields New Findings on Alcoholic Fatty Liver (Serum vitamin D levels are inversely related with non-alcoholic fatty liver disease independent of visceral obesity in Chinese postmenopausal women)

By a News Reporter-Staff News Editor at Gastroenterology Week — Investigators publish new report on Alcoholic Liver Diseases. According to news reporting originating in Shanghai, People’s Republic of China, by NewsRx journalists, research stated, “The aim of the present study was to investigate the association between serum vitamin D levels and both visceral adipose and with non-alcoholic fatty liver disease (NAFLD) in Chinese postmenopausal women. Four hundred and fifty-one postmenopausal women between 45 and 74years of age (mean (+/- SD) age 57.3 +/- 4.6years) were enrolled in the study.”

The news reporters obtained a quote from the research from Shanghai Jiao-Tong University, “All subjects participated in the Shanghai Obesity Study between June and August 2011 and underwent abdominal magnetic resonance imaging and an abdominal ultrasonography. Patients with a visceral fat area (VFA) 80cm(2) were classified as abdominally obese. Serum 25-hydroxyvitamin D-3 (25(OH)D-3) levels were measured with an electrochemiluminescence immunoassay. The prevalence of NAFLD in the study population was 34.8% (n=157). Women with abdominal obesity had significantly lower serum 25(OH)D-3 levels than those without abdominal obesity (median (interquartile range) 11.23 (8.64-14.12) vs 12.56 (9.41-15.98)ng/mL, respectively; P<0.01). Regardless of abdominal obesity status, serum 25(OH)D-3 levels in patients with NAFLD were lower than those without non-NAFLD (11.14 (8.63-13.81) vs 12.92 (9.48-16.37) ng/mL (P <0.05) for those without abdominal obesity; 10.86 (8.61-13.56) vs 11.55 (8.82-16.38) ng/mL (P <0.05) for those with abdominal obesity). Partial correlation analyses demonstrated a negative correlation between serum 25(OH)D-3 levels and VFA (P <0.05). Logistic regression analysis revealed that high serum 25(OH)D-3 levels were a protective factor against NAFLD after adjusting for risk factors such as VFA.”

According to the news reporters, the research concluded: “Independent of visceral obesity, vitamin D is inversely correlated with NAFLD in Chinese postmenopausal women.”

For more information on this research see: Serum vitamin D levels are inversely related with non-alcoholic fatty liver disease independent of visceral obesity in Chinese postmenopausal women. Clinical and Experimental Pharmacology and Physiology, 2015;42(2):139-145. Clinical and Experimental Pharmacology and Physiology can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell Clinical and Experimental Pharmacology and Physiology.

Our news correspondents report that additional information may be obtained by contacting Z.G. Lu, Shanghai Jiao Tong University, Affiliated Peoples Hosp 6, Shanghai Key Clin Center Metab DisShanghai Key Lab, Dept. of Endocrinol & MetabShanghai Clin Center Diabet, Shanghai 200233, People’s Republic of China. Additional authors for this research includeX.P. Pan, Y.Q. Hu, Y.P. Hao, Y.Q. Luo, X. Hu, X.J. Ma, Y.Q. Bao and W.P. Jia.

Keywords for this news article include: Asia, Shanghai, Alcoholism, Bariatrics, Overnutrition, Abdominal Obesity, Diet and Nutrition, Fatty Liver Disease, Nutrition Disorders, Alcoholic Fatty Liver, Alcoholic Liver Diseases, Digestive System Diseases,People’s Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2015, NewsRx LLC

Articles featured in Life Extension Daily News are derived from a variety of news sources and are provided as a service by Life Extension. These articles, while of potential interest to readers of Life Extension Daily News, do not necessarily represent the opinions nor constitute the advice of Life Extension.

 

Source : Life Extension

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