Vitamin D supplements do not improve symptoms or treatment

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Asthma is a chronic disease that affects more than 25 million people in the US. It is characterized by inflammation and narrowing of the airways that transport air to and from the lungs.

The research team, led by Dr. Mario Castro of the Washington University School of Medicine in St. Louis, MO, note that in children and adults who have asthma, low vitamin D levels have been associated with abnormal lung function, an increase in asthma flare-ups and lower response to treatment, such as corticosteroids.

Some studies have indicated that vitamin D supplementation may reduce inflammation and promote effectiveness of corticosteroids for asthma patients, but the Washington University team wanted to investigate further.

For their study, the researchers randomized 408 asthma patients with low vitamin D levels to one of two groups.

Findings ‘do not support vitamin D supplementation as a treatment for asthma’

Participants in the first group were required to take an initial 100,000 IU dose of vitamin D3, before taking a 4,000 IU dose daily for 28 weeks. Subjects in the second group were required to follow the same routine with a placebo. All participants continued with their usual corticosteroid treatment – inhaled ciclesonide.
Researchers found that vitamin D3 supplements did not reduce symptoms in asthmatics with low vitamin D levels, or improve treatment.
At the end of the study period, the research team found that taking vitamin D3 alongside ciclesonide did not reduce the rate of initial treatment failure, compared with patients who took the placebo.

Treatment failure was defined as a decline in lung function and increased use of systemic steroids, beta-antagonists and use of health care institutions.

In detail, 28% of patients taking vitamin D3 experienced at least one treatment failure within 28 weeks, compared with 29% in the placebo group. The most common cause of treatment failure was down to the need for increased or inhaled systemic steroids or an increase in frequency of asthma symptoms.

Source: medical news today

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  192. Hands down, Apple’s app store wins by a mile. It’s a huge selection of all sorts of apps vs a rather sad selection of a handful for Zune. Microsoft has plans, especially in the realm of games, but I’m not sure I’d want to bet on the future if this aspect is important to you. The iPod is a much better choice in that case.

  193. I’ll gear this review to 2 types of people: current Zune owners who are considering an upgrade, and people trying to decide between a Zune and an iPod. (There are other players worth considering out there, like the Sony Walkman X, but I hope this gives you enough info to make an informed decision of the Zune vs players other than the iPod line as well.)

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  199. Apple now has Rhapsody as an app, which is a great start, but it is currently hampered by the inability to store locally on your iPod, and has a dismal 64kbps bit rate. If this changes, then it will somewhat negate this advantage for the Zune, but the 10 songs per month will still be a big plus in Zune Pass’ favor.

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  201. Zune and iPod: Most people compare the Zune to the Touch, but after seeing how slim and surprisingly small and light it is, I consider it to be a rather unique hybrid that combines qualities of both the Touch and the Nano. It’s very colorful and lovely OLED screen is slightly smaller than the touch screen, but the player itself feels quite a bit smaller and lighter. It weighs about 2/3 as much, and is noticeably smaller in width and height, while being just a hair thicker.

  202. Hands down, Apple’s app store wins by a mile. It’s a huge selection of all sorts of apps vs a rather sad selection of a handful for Zune. Microsoft has plans, especially in the realm of games, but I’m not sure I’d want to bet on the future if this aspect is important to you. The iPod is a much better choice in that case.

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  205. Apple now has Rhapsody as an app, which is a great start, but it is currently hampered by the inability to store locally on your iPod, and has a dismal 64kbps bit rate. If this changes, then it will somewhat negate this advantage for the Zune, but the 10 songs per month will still be a big plus in Zune Pass’ favor.

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  208. The new Zune browser is surprisingly good, but not as good as the iPod’s. It works well, but isn’t as fast as Safari, and has a clunkier interface. If you occasionally plan on using the web browser that’s not an issue, but if you’re planning to browse the web alot from your PMP then the iPod’s larger screen and better browser may be important.

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  213. I’ll gear this review to 2 types of people: current Zune owners who are considering an upgrade, and people trying to decide between a Zune and an iPod. (There are other players worth considering out there, like the Sony Walkman X, but I hope this gives you enough info to make an informed decision of the Zune vs players other than the iPod line as well.)

  214. The new Zune browser is surprisingly good, but not as good as the iPod’s. It works well, but isn’t as fast as Safari, and has a clunkier interface. If you occasionally plan on using the web browser that’s not an issue, but if you’re planning to browse the web alot from your PMP then the iPod’s larger screen and better browser may be important.

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