What Exactly is Gene Testing & Why Are So Numerous Young Indians Embracing it

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As scientists the world over are busy trying to find the elusive elixir of life that can defy ageing and make you disease-free in golden years, gene-testing — a technology that scans DNA instructions you inherited from your parents to spot genetic disorders — is now gaining ground among Indians, especially the young.

According to diagnostics firms and health providers, gene-testing methods can not only find out what diseases you are prone to but also provide customised solutions to nip them in the bud and herald a new health era for you.

The approach, they stress, needs a fresh look at a time when scientists the world over are struggling to find new antibiotics to tackle resistant viruses and bacteria and onset of new life-threatening diseases.

“Knowledge of the genetic make-up (favourable vs unfavourable) may give the opportunity to take a pro-active step to avoid unfavourable factors and prompt the person to visit the doctor at initial symptoms,” says Dr Amit Verma, consultant (molecular oncology and cancer genetics) at Max Hospitals in New Delhi.

He is witnessing a surge in healthy young individuals coming to his clinic for gene-testing. The reason to go for such testing is simple: It can identify increased risks of health problems, allowing you to choose personalised treatments or assess responses to treatments. “The concept of gene testing is quite new to the entire medical field. However, scientifically, it is an established concept. The broader strategy would be to create awareness among the doctors first, followed by awareness amongst the people,” adds Dr Amol Raut, CEO of the Pune-based gene diagnostics firm GeneSupport.

Unfortunately, genetically associated factors cannot be reversed but the action will certainly minimise the possibility of acquiring bad health. “The genes related to all conditions such as cancer, metabolic diseases, congenital diseases, lifestyle or other diseases are scanned, which helps in identifying missing pieces of information or even inappropriate information in genes,” explains Dr Raut, also the chief consultant (R&D) of GeneOmbio Technologies that provides various gene diagnostic services.

Individuals are usually born with such altered information and scanning the genes helps in understanding the tendency, chances or risk towards a particular undesired body condition.

“Further, such techniques can also be used to identify the stage of a disease as it happens in case of cancer progression determination. This information can be used to further change or modify therapy, diet, exercise and even lifestyle in certain cases to provide personalised information,” Dr Raut stresses.

According to Dr Kshitiz Murdia, an IVF expert at the Indira Infertility Clinic in New Delhi, genetic testing will be the future “as we would be able to eliminate certain inherited or genetic disorders from families who have those.” “In the last four-five years, genetics has progressed a long way through. With the new generation sequencing possible in the human genome, the whole genome can be sequenced and can even identity single gene disorders and some 600-700 other disorders,” he said.

He too is seeing an increase in the number of people who want to go in for genetic testing. “At present, we are able to identify aneuploidies (presence of an abnormal number of chromosomes in a cell), thalassemia (inherited blood disorder) and other disorders which are a common cause of abortions or disability causing childhood disorders,” Dr Murdia elaborates.

Four years back when Hollywood actor Angelina Jolie decided to have both her breasts removed as she carried a gene mutation that put her at a high risk of developing breast cancer, people across the world were left shocked. But her decision had improved awareness of reconstructive breast surgery options among women, revealed a recent Swedish study published in the journal Cancer.

Genetic alterations or mutations are permanent features of the genetic make-up. “It cannot be reversed or fixed, but attempts at using gene therapy in few disorders like cystic fibrosis have proven to be beneficial in modifying the disease to some extent,” Dr Verma told IANS.

Gene sequencing can also be used to screen new-born babies and commercial egg and sperm donors to find if they are free from any genetic disorder. “Most importantly, embryos can be tested for rare genetic or hereditary disorders by next-generation sequencing platform (whole genome scanning), enabling transfer of healthy embryos back to the mother and delivering a normal child,” emphasises Dr Murdia.

Pricing is also a key factor for such advanced test methods. The cost of gene tests depends upon the number of biomarkers being analysed. “This increases the price bandwidth for tests which may range from an average of Rs.1,000 to Rs.10,000. The price range from lowest to highest may cover one to three conditions to several conditions, respectively,” Dr Raut said.

The next-generation sequencing platform is the future that can be used to scan the entire human genome and detect all known biomarkers. “In such cases, the average cost may run into a few lakhs (of rupees) including associated consultation from the doctors. However, such comprehensive analysis is the future of diagnostics,” Dr Raut says.

Source- Ndtv food

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  129. Apple now has Rhapsody as an app, which is a great start, but it is currently hampered by the inability to store locally on your iPod, and has a dismal 64kbps bit rate. If this changes, then it will somewhat negate this advantage for the Zune, but the 10 songs per month will still be a big plus in Zune Pass’ favor.

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  165. If you’re still on the fence: grab your favorite earphones, head down to a Best Buy and ask to plug them into a Zune then an iPod and see which one sounds better to you, and which interface makes you smile more. Then you’ll know which is right for you.

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  176. The Zune concentrates on being a Portable Media Player. Not a web browser. Not a game machine. Maybe in the future it’ll do even better in those areas, but for now it’s a fantastic way to organize and listen to your music and videos, and is without peer in that regard. The iPod’s strengths are its web browsing and apps. If those sound more compelling, perhaps it is your best choice.

  177. I’ll gear this review to 2 types of people: current Zune owners who are considering an upgrade, and people trying to decide between a Zune and an iPod. (There are other players worth considering out there, like the Sony Walkman X, but I hope this gives you enough info to make an informed decision of the Zune vs players other than the iPod line as well.)

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  181. The Zune concentrates on being a Portable Media Player. Not a web browser. Not a game machine. Maybe in the future it’ll do even better in those areas, but for now it’s a fantastic way to organize and listen to your music and videos, and is without peer in that regard. The iPod’s strengths are its web browsing and apps. If those sound more compelling, perhaps it is your best choice.

  182. Apple now has Rhapsody as an app, which is a great start, but it is currently hampered by the inability to store locally on your iPod, and has a dismal 64kbps bit rate. If this changes, then it will somewhat negate this advantage for the Zune, but the 10 songs per month will still be a big plus in Zune Pass’ favor.

  183. I’ll gear this review to 2 types of people: current Zune owners who are considering an upgrade, and people trying to decide between a Zune and an iPod. (There are other players worth considering out there, like the Sony Walkman X, but I hope this gives you enough info to make an informed decision of the Zune vs players other than the iPod line as well.)

  184. Zune and iPod: Most people compare the Zune to the Touch, but after seeing how slim and surprisingly small and light it is, I consider it to be a rather unique hybrid that combines qualities of both the Touch and the Nano. It’s very colorful and lovely OLED screen is slightly smaller than the touch screen, but the player itself feels quite a bit smaller and lighter. It weighs about 2/3 as much, and is noticeably smaller in width and height, while being just a hair thicker.

  185. This is getting a bit more subjective, but I much prefer the Zune Marketplace. The interface is colorful, has more flair, and some cool features like ‘Mixview’ that let you quickly see related albums, songs, or other users related to what you’re listening to. Clicking on one of those will center on that item, and another set of “neighbors” will come into view, allowing you to navigate around exploring by similar artists, songs, or users. Speaking of users, the Zune “Social” is also great fun, letting you find others with shared tastes and becoming friends with them. You then can listen to a playlist created based on an amalgamation of what all your friends are listening to, which is also enjoyable. Those concerned with privacy will be relieved to know you can prevent the public from seeing your personal listening habits if you so choose.

  186. Apple now has Rhapsody as an app, which is a great start, but it is currently hampered by the inability to store locally on your iPod, and has a dismal 64kbps bit rate. If this changes, then it will somewhat negate this advantage for the Zune, but the 10 songs per month will still be a big plus in Zune Pass’ favor.

  187. Hands down, Apple’s app store wins by a mile. It’s a huge selection of all sorts of apps vs a rather sad selection of a handful for Zune. Microsoft has plans, especially in the realm of games, but I’m not sure I’d want to bet on the future if this aspect is important to you. The iPod is a much better choice in that case.

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  189. This is getting a bit more subjective, but I much prefer the Zune Marketplace. The interface is colorful, has more flair, and some cool features like ‘Mixview’ that let you quickly see related albums, songs, or other users related to what you’re listening to. Clicking on one of those will center on that item, and another set of “neighbors” will come into view, allowing you to navigate around exploring by similar artists, songs, or users. Speaking of users, the Zune “Social” is also great fun, letting you find others with shared tastes and becoming friends with them. You then can listen to a playlist created based on an amalgamation of what all your friends are listening to, which is also enjoyable. Those concerned with privacy will be relieved to know you can prevent the public from seeing your personal listening habits if you so choose.

  190. The new Zune browser is surprisingly good, but not as good as the iPod’s. It works well, but isn’t as fast as Safari, and has a clunkier interface. If you occasionally plan on using the web browser that’s not an issue, but if you’re planning to browse the web alot from your PMP then the iPod’s larger screen and better browser may be important.

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  197. Zune and iPod: Most people compare the Zune to the Touch, but after seeing how slim and surprisingly small and light it is, I consider it to be a rather unique hybrid that combines qualities of both the Touch and the Nano. It’s very colorful and lovely OLED screen is slightly smaller than the touch screen, but the player itself feels quite a bit smaller and lighter. It weighs about 2/3 as much, and is noticeably smaller in width and height, while being just a hair thicker.

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